Catalog Number - 85018-PG2

The 85018‑PG2 Cogent RP C18 ABX™ Guard Column Cartridges are engineered to extend the life of analytical columns used in extreme pH workflows, providing effective protection against particulates, strongly retained compounds, and matrix contamination.

Packed with 10 µm RP C18 ABX™ stationary phase, these cartridges feature bulky end‑capping on high‑purity silica, ensuring chemical stability and performance across a wide pH range (2–12).

Designed for Analytical Columns (3.0–4.6 mm ID)

• Compatible with:

  • 3.0 mm ID solvent‑saving columns

  • 4.0 mm ID analytical columns

  • 4.6 mm ID standard HPLC columns

✅ Maintains chromatographic selectivity and method integrity

Purpose of Guard Columns

• Protect analytical columns from:

  • Particulate contamination

  • Strongly retained acidic or basic compounds

  • Matrix buildup and fouling

• Extend column lifetime

• Maintain retention time reproducibility and peak shape

• Reduce downtime and replacement costs

10 µm Guard Media – Preparative Scouting Protection Layer

• Designed for:

  • High‑flow conditions

  • Low backpressure operation

  • Durability under heavy sample loads

✅ Ideal for:

• Preparative method scouting workflows

• Scale‑up method development under extreme pH conditions

Why Choose RP C18 ABX™ Guard Cartridges (10 µm)

Matched Extreme pH Chemistry

• Same ABX™ stationary phase as analytical column

• Maintains selectivity and retention behavior

• Supports pH 2–12 operation

Enhanced Column Protection

• Captures contaminants before reaching the main column

• Reduces irreversible adsorption and column degradation

Workflow Efficiency

• Minimizes column replacement frequency

• Supports high‑throughput analytical and preparative workflows

Cogent RP C18 ABX™ Advantages

Extreme pH Stability

• Operates reliably across pH 2–12

• Ideal for acidic and basic analytes

Bulky End‑Capping

• Minimizes unwanted secondary interactions

• Improves peak symmetry and reproducibility

Durable Construction

• Stainless steel cartridge body

• Stainless steel frits

• PEEK sealing components

✅ Designed for demanding analytical environments

Important Usage Notes

• ⚠️ Must be used with a compatible guard column holder system

• Designed for analytical HPLC systems (3.0–4.6 mm ID columns)

• Ideal for extreme pH method development and preparative scouting workflows

• Replace regularly to maintain optimal column protection and performance

Helpful Resource & Link

• 👉 View guard column holders and compatibility options for these cartridges